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pentobarbital will minimize the level or effect of naloxegol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with solid CYP3A4 inducers will not be advisedpentobarbital will lessen the level or effect of zolpidem by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Significance Not known.